The extracellular matrix (ECM) is dynamically remodeled by cells during development, normal tissue homeostasis and in a variety of disease processes. MT1-MMP display decreased turnover and endocytosis of ECM fibronectin. MT1-MMP adjusts ECM fibronectin redecorating by marketing extracellular cleavage of fibronectin and by controlling 51-integrin endocytosis. Our Klf6 data also present that fibronectin polymerization stabilizes… Continue reading The extracellular matrix (ECM) is dynamically remodeled by cells during development,