2G12 is a broadly neutralizing anti-HIV-1 monoclonal human being IgG1 antibody reactive with a high-mannose glycan cluster on the surface of glycoprotein gp120. no evidence of equilibrium between domain-exchanged and conventional forms. Two substitutions not previously implicated, AH14 and EH75, are FK866 the most crucial for domain exchange, together with IH19 at the VH/VH interface… Continue reading 2G12 is a broadly neutralizing anti-HIV-1 monoclonal human being IgG1 antibody